Hi Jane. If you stick to the main body of the article you will find a very clear list of drugs to avoid. What you see in the comments are people asking about all sorts of things. The comment regarding seizures refers to a known link between isoxazoline insecticides and dogs prone to seizures, and has nothing to do with the MDR1 gene. Your confusion is a good example of the problem with forums on any subject.

Andrew your andwers to some of these MDR1 gene and seizures are confusing and you’ve contradicted yourself as to your recommendations on the flea and worm issues and what’s safe
A question was posted telling you a dog had seizures after nexgard and you recommended comfortis and to others you say that nexgard is safe for MDR1
Please clarify what’s really true. Our dogs are our babies.

Hi Christy. Given the large number of choices, it’s easier to say what to avoid, and you’ll find those listed in the article.

Hi Becky. That sounds like a version of the well-known side effects of this class of drug, rather than anything specific to MDR one. You are best to avoid these products, as there are plenty of good flea controls such as Comfortis. However if ticks are a risk than please talk to your vet about what to do in your local area, because there are no products of equal efficacy.

Hi Robin. If the drug that was used is not listed above, you might also visit our page on seizures and dog flea treatments.

Hi Shirley. It’s more likely that a particular staff member at PetBarn has advised this, rather than it being policy of the organisation. As you’ll see, there is no reason for that combination to be of concern. As for what is the best, all you need to worry about is making sure that all the drugs you use are not featured in the list above.